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These findings support the role of TMPRSS2 as a regulator of ghrelin and provide initial evidence for its potential as a therapeutic target in this obesity-associated impairment of glucose homeostasis

In terms of iron uptake, diabetic conditions increase the expression of ZRT/IRT-like protein 14 (ZIP14), divalent metal transporter 1 (DMT1), and transferrin receptor 1 (TFR1)

Notably, her thrombophilia screening revealed a JAK2 V617F mutation, a known risk factor for unusual-site blood clots