the first and second cysteines are disulfide bonded to each other because they were available first during protein translation
It is considered a mitochondrial-derived peptide (MDP) and functions as a metabolic regulator
When released (e.g., with vesicle depletion by reserpine or amphetamine) [69,70,152] it can substitute disturbed dopamine (i.e., shortage (reserpine) [69] or excess (amphetamine) [70]) as competing successfully for sites at dopamine receptors (i.e., counteracting the adverse effects of both dopamine agonists [70,152,153] and dopamine antagonists [68,70,152])
CuHeal excludes diabetes, peripheral vascular disease, immunodeficiency, pregnancy, breastfeeding, recent immunosuppressant or cytotoxic medication use, and several wound-healing risk factors [7]
All other data are available from the corresponding authors upon request