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Metformin passes into breast milk in minimal amounts, whilst insulin molecules are too large to transfer significantly and would be digested in the infant's gastrointestinal tract

Adults on GLP-1 receptor agonists for extended periods show reduced risk of cognitive decline and dementia in several observational and trial datasets, with effect sizes ranging from modest single-digit reductions to much larger ones, depending on the cohort

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Randomized clinical trials are more important than online extrapolation

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