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The formation of ice crystals during the freeze-thaw cycle can physically shred the delicate peptide chains, destroying the compound just as effectively as heat

Patients with contraindications or non-responsive to NSAIDs may benefit from opioids such as meperidine [114], butorphanol [115], or hydromorphone [110]

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There has also been a suggestion it might help with cognitive performance, such as improved focus and concentration, but clinical trials are needed to confirm this

Elevated levels of plasma biomarkers, especially markers of systemic inflammation (interleukin-6 and interleukin-8), epithelial injury (receptor for advanced glycation end products and surfactant protein D) and endothelial injury (angiopoietin 2), as well as dysregulated coagulation markers (low levels of protein C and high levels of plasminogen activator inhibitor 1), have all been associated with adverse SARS results