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A new GLP-1 analogue with prolonged glucose-lowering activity in vivo via backbone-based modification at the N-terminus

Introduction In 1980, a Met-enkephalin-like pentapeptide was found to exhibited growth hormone (GH)-releasing activity ( in vitro , it specifically promoted GH release without affecting the secretion of other anterior pituitary hormones, including luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone, and prolactin

doi: 10.14814/phy2.12907 148 GreenDJMaioranaAO'DriscollGTaylorR