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Bioengineered 12 (1), 117126

Recent research surprisingly demonstrated that serotonin-secreting enterochromaffin cells were the major chemical sensors for vagal afferent neurons in the proximal duodenum, whereas Glp1r -expressing ND neurons predominantly innervated muscle layers of the stomach and responded to stretch rather than to chemical stimuli entering the duodenum 46

It does not appear to engage the vagal and peripheral pathways that mediate the gastrointestinal punishment of GLP-1 agonism

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