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Other signal transduction systems and metabolic pathways involved in the MGB-based cause of depression include the endocannabinoid system, CAMKII-CREB and MAPK signaling, and glycerophospholipid metabolism

General Principle If nausea is severe at any step, stay at the current dose for an additional 24 weeks before increasing

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Treatment with semaglutide results in significant weight loss, reduced energy intake, decreased appetite and food carvings and decreased relative preference for energy-dense foods [19]

The most common side effects are gastrointestinal and usually temporary: - Nausea (most common, especially in first weeks) - Mild constipation or diarrhea - Reduced appetite (this is also the intended effect!) - Occasional fatigue during dose increases Our physicians use a gradual dose-escalation protocol if needed, specifically designed to minimize these effects