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In patients treated with GLP-1RAs and tirzepatide, gastrointestinal side effects such as nausea and vomiting are common but do not significantly contribute to weight loss

Likely not for endometriosis specifically, since these medications are not approved for this indication

GLP-1 Receptor Agonist Discontinuation Among Patients with Obesity and/or Type 2 Diabetes

The long half-life is driven by albumin binding (greater than 99% bound), reduced DPP-4 degradation due to the Aib8 substitution, and slowed renal clearance of the larger albumin-bound complex

Role of GLP-1 in inflammatory regulation in IBD To date, researchers focused mainly on the anti-diabetic and anti-atherosclerotic effects of GLP-1 agonists, while the GI effects remained poorly understood