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doi:10.1186/s41043-015-0032-y [28] Woodford KB

Elevated intracellular cAMP then drives the following cascade, as characterised in Mel-Ab and B16 melanocyte cell line preparations: MC1R cAMP PKA CREB phosphorylation MITF upregulation tyrosinase expression Picture it this way: MT1 docks at the extracellular binding pocket of MC1R, triggering a conformational shift that couples the receptor to the Gs protein

Precautions *By taking this medicine on an empty stomach, the active ingredients will be absorbed from the stomach and will be effective