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The kidneys contribute to GH degradation and as a result, GH half-life is increased in patients with CKD due to decreased renal clearance (73) ( Figure 4 )

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8,40 The liver, similar to islet beta-cells, does not depend on insulin to uptake glucose from circulation

Notably, we explore prospective targets and candidate intervention agents for ferroptosis, paving the way for novel ferroptosis regulators and approaches to intervention in the treatment of multiple human diseases