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Systematic reviews and meta-analyses of randomized trials have further confirmed that while GLP-1RAs lower body weight and fat mass significantly, they do not appear to exert an independent detrimental effect on skeletal muscle index beyond expected proportional reductions [25]

More importantly, it might mask other underlying health issues that need attention

After being granted a fast-track designation for weight loss by the FDA (October 22), tirzepatide is expected to be approved for obesity later this year

Bucciarelli, L

Growth Horm IGF Res 11:247249 Frane J, Bailly J, Chernausek SD, Kuntze J (2006) Growth responses to higher dose recombinant human IGF-I (rhIGF-I) in children with severe primary IGF-I deficiency (IGFD) due to growth hormone insensitivity (GHIS) (abstract P03-619)