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DSIP as a modulator of the human central nervous system

For example, the administration of HPL to the lateral ventricles of rats subjected to focal ischemia induced by permanent distal middle cerebral artery occlusion significantly enhanced the proliferation of endogenous neural stem cells and angiogenesis in the SVZ and in the perilesion cortex and improved neurobehavioral outcomes

25 Another study demonstrated that the ferroptosis inducer, elastin, regulates lipid peroxidation through ACSL4 rather than GPX4

Abbreviations CQ: Chloroquine CSCs: Cancer stem cells ER: Estrogen receptor-alpha GPxs: Glutathione peroxidases GSH: Glutathione HCC: Hepatocellular carcinoma hiPSC-MSCs: Mesenchymal stem cells drived from human induced pluripotent stem cells IBC: Inflammatory breast cancer IH: Isorhamnetin LOH: Loss of heterozygosity MnSOD: Manganese superoxide dismutase NAC: N -acetylcysteine PHGPx: Phospholipid GPx ROS: Reactive oxygen species TNBC: Triple-negative breast cancer TFAP2C: Transcription factor AP-2 gamma References Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A

Braz J Psychiatry