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Mechanism of the inhibitory effect of zwitterionic drugs (levofloxacin and grepafloxacin) on carnitine transporter (OCTN2) in Caco-2 cells

This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity

Despite of the exhaustive information available about GST super family, still the knowledge about the presence and diverse functions of GSTs is lacking

GABA), stacking them theoretically mitigates the overstimulation of Semax while preventing the lethargy sometimes associated with anxiolytics

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