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Serotonin, dopamine, GABA, and glutamate all respond to GLP-1 receptor activation

It sounds a cautionary note for short-term use without a more comprehensive approach to weight management.' Image source: West S, Scragg J, Aveyard P et al., The BMJ 2026 (CC BY 4.0) The Oxford team systematically reviewed 37 studies tracking more than 9,000 adults who stopped taking weight management medicines after being on them for an average of 39 weeks of treatment

In this narrative review, we summarize the rationale, receptor biology, pharmacological mechanisms, inflammatory signaling hypotheses, clinical evidence, safety concerns, and implementation challenges related to GLP-1RA use in obesity-related KOA

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Which comorbidities matter most The most commonly recognized comorbidities are the ones that show weight is not just a cosmetic concern