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The present study, for the first time, demonstrates an underlying mechanism for the activation of eNOS by BPC 157 on stimulating the Cav-1 phosphorylation and reducing the binding of eNOS to Cav-1

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Ethics declarations Conflict of interest The Authors Rosaria Maddalena Ruggeri, Camilla Virili, Edoardo Mocini, Marco Centanni, Salvatore Cannav, Mario Rotondi, Laura Croce, Silvia Migliaccio, declare no conflicts of interest

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reported that approximately 15% of patients who were treated with intravenous acetylcysteine had an anaphylactoid reaction within 2 hours after the initial infusion and that increasing the infusion time from 15 to 60 minutes did not alter the rate of adverse events