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If they are going to be used they should be made according to a USP monograph or be a component of an approved drug, if no monograph exists it must be on the 503A Bulk List, and it must be manufactured in an FDA registered facility with a proper certificate of analysis

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Proportion of participants achieving clinically meaningful weight-loss milestones

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Levy also mentions that, in studies, less than 5% of patients reported that they stopped taking the medication due to side effects