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It features a heterodifunctional molecule integrating two crucial ligands: one targeting and binding to the protein of interest, and another engaging with an E3 ligase, a pivotal element within the ubiquitin-proteasome system tasked with marking proteins for degradation (Zeng et al., 2021)

A myeloid leukemia model was created in mice by functionally disrupting both Tet2 and Tet3 in HSPCs, subsequently followed by transplantation

They include ankylosing spondylitis, reactive arthritis and psoriatic arthritis

BioFactors (Oxford, England), 43 (1), 132140