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This sparked their approval as prescription drugs for weight management in obesity, making GLP-1 drugs one of the biggest pharmacological breakthroughs of the early 21st century

GLP-1-based therapy was developed in the 1990s and treatment with daily injectable GLP-1 receptor agonists and oral dipeptidyl peptidase-4 (DPP-4) inhibitors was introduced in the 2000s [2]

For short trips (less than one week), many users prefer keeping their injection on home time rather than adjusting to the destination time zone

The use of "GLP-1" terminology in supplement marketing reflects conceptual positioning and does not indicate FDA approval or physiological equivalence to prescription GLP-1 medications