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GLP-1 plays a protective role in hippocampal neuronal cells by activating cAMP-CREB-BDNF signaling pathway against CORT+HG-induced toxicity

Weeks 5 to 8: the dose escalation phase Most GLP-1 protocols involve dose escalation every four weeks

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Much efforts have been invested in peptide and peptidomimetic chemistries 6,7,8,9,10,11 to address those weaknesses in the hope of finding an alternative to peptides and recently foldamer research has attracted much interest 12,13,14,15

Both therapies, though developed for different purposes, converge on a similar mechanism: the enhancement of GLP-1 secretion and improvement in gut hormone signaling