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Therefore, different configurations of CTR and RAMP within the complex might dictate the activation of one or more of the various intracellular pathways, leading to the expression of the physiological effects

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Noteworthy, analyzing results according to baseline vasculogenic ED degree category, at study completion, IIEF-6 score was significantly increased in both subgroups of patients with mildmoderate and severe vasculogenic ED, whereas PSV was significantly increased only in the subgroup of patients with mildmoderate vasculogenic ED, despite a significantly lower baseline PSV in l-ARG compared to placebo group

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RNA 9 , 331345 (2003)