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It has further surprisingly and unexpectedly been found that multiple agent therapy, including but not limited to wherein each agent is independently a sub-therapeutic dose, with either sequential or concurrent administration of the agents, will produce the desired pharmacological response, such as an erection sufficient for sexual intercourse, in patients with nerve damage, such as resulting from a prostatectomy or spinal cord injury, who are marginally responsive to a PDE-5 inhibitor such as sildenafil
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100 ms were perfused to measure the whole-cell desensitization kinetics
In the trials, the most common were: Nausea Diarrhea Constipation Vomiting These effects were usually mild to moderate and tended to show up early in the first few weeks of treatment or right after a dose increase
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