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doi: 10.1016/j.omtn.2022.01.008 39 ZhengADuYWangYZhengYNingZWuMet al

Individuals with serum IGF-I level at or above the median value (140 g/L) had half the risk for heart failure (hazard ratio, 0.49 [95% CI, 0.26 to 0.92]) of those with serum IGF-I levels below the median

Increased expression of insulin/insulin-like growth factor-1 hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects

It is important to note that confirmation of ferroptosis in erythrocytes can be challenging due to the impossibility to assess characteristic alterations of organelles (especially mitochondria, absent in mature RBCs) and the complex ferroptosis signaling requiring epigenetic, transcriptional, and post-translational regulation