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(2) genetic manipulation or variations in clock and clock-controlled genes

In one reported case, for example, despite being previously healthy, a 16-year-old girl developed recurrent exercise-induced rhabdomyolysis that resulted in eight hospitalizations [24]

Novo Nordisk also agreed to spend up to $1.1 billion last year to acquire Inversago Pharma, gaining an experimental oral drug called monlunabant thats designed to block a cannabinoid receptor important in regulating appetite

Over the past decade, these agents have expanded into obesity treatment at higher doses, producing unprecedented weight loss in nondiabetic individuals (e.g

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