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To better understand the clinical utility of flavonoids and assess their potential as adjunctive therapies, the following areas need to be further investigated: structural optimization, drug targeting, and inhalation delivery systems, standardized research reporting, and multi-omics data integration, along with rigorous multicenter clinical trials and comprehensive safety evaluations

Our heterogeneous primary cortical culture, representing multiple cortical neuronal subtypes, showed no significant decrease in overall viability, supporting the interpretation that the observed cellular effects stem from metabolic and functional disruptions rather than from degeneration

M., Koning, A., Kuhnle, G

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