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Therefore, we evaluated changes in the expression of ROS/TGF/SMAD pathway molecules and the effect of GSH thereon in cultured primary PSCs

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7 Subcutaneous semaglutide was approved in 2021 and 2022 as Wegovy for weight loss in patients 12 and older after the STEP1 trial showed patients who took subcutaneous semaglutide had a -14.9% body weight reduction (-15.3kg) compared to -2.4% (-2.6kg) with placebo after 68 weeks

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In wild-type mice, cagrilintide activates c-Fos-expressing neurons in the dorsal vagal complex (DVC), lateral parabrachial nucleus (LPBN), area postrema, and nucleus tractus solitarius brainstem regions critically involved in satiety signaling and suppression of food intake