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Jacks T, Shih TS, Schmitt EM, Bronson RT, Bernards A, Weinberg RA

Spinal injury Spinal cord injuries could cost millions of dollars of care over the course of the victims lifetime, especially when those injuries result in partial or complete paralysis, such as paraplegia or quadriplegia

Such an improvement, detected after the first 60 days of treatment, persisted throughout the treatment period, lasting 4 months

A parent application filed early in drug development before clinical proof of concept, before specific structural characterization of the APIs binding mode, before formulation work is complete often describes broad biological targets or mechanism of action at a level of generality that satisfies early-stage patenting goals but cannot support the more specific claims an applicant wants to assert from the same parent priority date years later

reported on three patients with metastatic malignant melanoma of the CNS treated with vemurafenib