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High-Fat Meals Maximum Absorption Delay Fat is the most effective macronutrient for reducing peak BAC because it takes the longest to digest and triggers the pyloric valve to remain most closed

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A weight loss rate of approximately 1 to 2 pounds per week is generally considered safe and sustainable

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In line with this, the gastric emptying delay induced by GLP-1RAs is dependent on the presence of GLP-1Rs on these vagal afferents (Imeryuz et al., 1997)