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Nevertheless, prompt diagnosis and treatment are required to prevent extensive and irreversible damage to the body

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PLoS ONE 9 , e100778 (2014)

For example, antibodies containing a reactive aldehyde handle have been produced using formylglycine generating enzyme (FGE), an enzyme recognizing the sequence CxPxR and oxidizing the cysteine residue to form formylglycine in the pioneering work of Bertozzi et al