For both ingredients, a few universal principles apply: patch test before full-face use, introduce one active at a time, avoid combining with incompatible ingredients, and stop use if you experience persistent irritation, allergic reaction, or unexpected pigmentary change
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Previous experiments have found that exendin-4 could reduce the pain-induced neuro-inflammatory response through the GLP-1R pathway, thereby promoting the recovery of cognitive function in mice (100)
In GlP-1 R-null mice, tirzepatide improved insulin sensitivity by enhancing glucose disposal in white adipose tissue in the absence of GLP-1 RA-induced weight loss