These early indicators help confirm biological activity while hair-specific results develop more slowly
Weight regain continued throughout the entire follow-up period without plateauing, and cardiometabolic improvements that had occurred during treatment also reversed partially
Likewise, 2-aminoadipate, a product of lysine degradation associated with insulin resistance (13, 15), was also 6-fold lower in PBH versus Asx ( P = 0.001, FDR = 0.04) in the fasting state (Supplemental Figure 7B)
Rotating injection sites prevents lipodystrophy, a localized change in fat tissue that can develop from repeated injections in the same spot
Protocol components, including eligibility criteria, treatment strategies and follow-up definitions, were closely aligned with the original trials (Methods)