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485 These findings indicate that mitochondria iron overload, combined with ROS formation and subsequent ferroptosis, intensifies the cardiotoxic effects of DOX-induced cardiomyopathy and may be an important mechanism

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Within the nucleus, NF-B binds to specific gene promoter regions, initiating the transcription of key pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), IL-6, and IL-1 (Wang G

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Women using oral contraceptives should discuss the need for alternative or additional contraceptive methods during tirzepatide initiation and dose escalation

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A multicentre retrospective study from China found that high fasting glucose levels (7.0 mmol/l (126 mg/dl)) at admission was an independent predictor of increased mortality in patients with COVID-19 who did not have diabetes mellitus 61

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