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Because PT-141 can cause nausea, some people prefer to take it on an empty stomach, and then eat a light snack after administering (to possibly help settle the stomach once the drug is absorbed)

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Serra, D

Safety, tolerability and pharmacokinetics of GSK3389404, an antisense oligonucleotide for the treatment of chronic hepatitis B (CHB) infection: a randomized, double-blind, placebo-controlled, dose-escalation, first time in human study [abstract]