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The ADA Standards of Care 2024 acknowledge oxidative stress as a mechanistic contributor to diabetic complications but stop short of recommending specific antioxidant supplementation due to inconsistent clinical outcomes data
J., Davis, M
& Jain, M
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However, it is noteworthy that, while upregulation of glutamine metabolism is a phenomenon present in many cancer cells, recent studies have shown a decrease in glutamine metabolism in cholangiocarcinoma, glioblastoma multiforme, liver hepatocellular carcinoma, and thyroid carcinoma, demonstrating tissue heterogeneity in glutamine metabolism [40]
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