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Future directions should focus on integrating multiomics platforms (e.g., single-cell transcriptomics and spatial proteomics) to refine target selection paradigms while leveraging engineering innovations to lower translational barriers, ultimately bridging the gap between preclinical validation and clinical implementation

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Niacinamide (Vitamin B3): Niacinamide is known for its ability to improve the skin's barrier function, control sebum production, and reduce the appearance of hyperpigmentation