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10.1136/bmj.322.7297.1271

doi: 10.1111/cpr.12909 75 HallingJFPilegaardH

Additionally, glutathione disulfide (GSSG) is involved in the degradation of drug delivery systems containing disulfide bonds, which allows for targeted drug release in cancer therapy

Further consistent with this mechanism, Gem pretreatment did not suppress ferroptosis induced by the direct GPX4 inhibitor ML162, whose ability to induce ferroptosis is independent of intracellular GSH pools (Yang et al, 2014) (Fig 4F)

1 H NMR (400 MHz, Chloroform-d) = 8.65 (dd, J = 4.8, 2.6 Hz, 1H), 8.047.93 (m, 2H), 7.83 (td, J = 7.7, 2.2 Hz, 1H), 7.74 (dd, J = 8.1, 2.6 Hz, 1H), 7.32 (p, J = 3.3 Hz, 1H), 7.026.91 (m, 2H), 4.15 (dt, J = 8.6, 3.9 Hz, 2H), 3.83 (dt, J = 8.5, 3.7 Hz, 2H), 2.03 (dt, J = 8.4, 3.9 Hz, 2H)