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139 Uricosuric agents represent a secondary or alternative therapeutic option, with recent guidelines advocating their use in combination with XO inhibitors when monotherapy proves ineffective

Cao, J., Belousoff, M

Irritation: Azelaic acid is known to cause some initial itching, stinging, or burning, especially at higher concentrations

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The temperature employed to evaporate solvent from the microdroplets is not critical, but should not be that high that it degrades the agent employed in the preparation of a given microparticle, nor should it be so high as to evaporate solvent at such a rapid rate to cause defects in the wall forming material