An amidated C-terminal tyrosine is not tolerated for high affinity peptide interactions with the CTR in the absence of RAMPs
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It formally characterises DSIP as a still unresolved riddle acknowledging that no specific DSIP receptor has been confirmed, that the existence of DSIP-like endogenous peptides distinct from DSIP itself may account for a substantial proportion of DSIP-like immunoreactivity data, and that the most robust SWS-promoting activity in rodent studies has been demonstrated for synthetic DSIP structural analogues rather than native DSIP itself
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