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Several randomized, placebo-controlled trials have been conducted to determine whether homocysteine-lowering through folic acid, vitamin B 12 , and vitamin B6 supplementation reduces the incidence of CVD

The findings cited above are taken from preclinical, animal-model, and in vitro studies and are reported here for research context only

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While its safety profile was consistently favorable, the largest Phase IIb trial failed to show statistical significance for weight loss, and commercial development was halted in 2007.[2] Despite this, interest in AOD-9604 has continued in the compounding pharmacy and integrative medicine space, particularly given its safety data, its lack of IGF-1 stimulation, and emerging research around joint health

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