does glutathione increase glutamate and in schizophrenia: a 7T MRS study Frontiers | Ischemia-Triggered Glutamate Excitotoxicity

Aging Dis 6:349368

The intranasal GHK-Cu treatment was found to delay cognitive impairment, reduce amyloid plaques, and lower inflammation levels in the frontal cortex and hippocampus .37 Randomized controlled trials in human patients are needed to confirm the benefit of GHK-Cu for cognitive decline and Alzheimers disease as well as to evaluate safe and effective human dosing (the human dose equivalent of 15mg/kg in mice would be ~1.2mg/kg, though data on this or any other dosing nasally in humans is not currently available), but preliminary animal trials are promising

The molecule size makes penetrating the subcutaneous layers and then the bloodstream difficult

They are tightly controlled by mitochondrial dynamics and mitophagy (Rahman et al., 2022)

Missed Doses If a dose is missed, advise patients not to take an extra dose