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However, getting the dose right still matters for optimal results

PGC1 expression is controlled in skeletal muscles by PPAR, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

The good news is that early evidence on oral semaglutide suggests a potential advantage here: One study showed that oral semaglutide improved blood sugar and reduced body fat while not significantly affecting muscle mass in those with type 2 diabetes

Other nutrients have more specific indications like improving mitochondrial function, blood glucose metabolism or oestrogen stability

doi: 10.1073/pnas.2100050118 53 FlorosKVChawlaATJohnson-BerroMOKhatriRStamatouliAMBoikosSAet al