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The patient ends up in a worse body composition position than before treatment began

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Considering that OSAS patients often present with multiple comorbiditiessuch as hypertension, coronary artery disease, and diabetesfurther large-scale, long-term follow-up studies are needed to clarify tirzepatides safety in multimorbid populations (63, 64)

However, cardiovascular side effects (increased heart rate and blood pressure) led to FDA rejection despite promising efficacy data

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