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For oral administration, clinical trials have studied doses ranging from 1-30 mg daily, with typical protocols using 1-2 mg per dose on an empty stomach

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This is controlled by a complex reflex involving central neural control centres located in the lateral reticular formation of the medulla which are stimulated by the chemoreceptor trigger zones (CTZs) in the floor of the fourth ventricle, and also by vagal afferents from the gut

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