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2.3 Direct oral-gut translocation Oral bacteria directly colonize the gut via saliva, and more than 45% of individuals in the Human Microbiome Project exhibited overlapping bacterial genera between the oral cavity and stool (Segata et al., 2012), indicating that the transfer of oral bacteria to the gut is a frequent occurrence

Mechanisms studied in the literature This section summarises what is being studied , not what is claimed to occur in humans

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Results Establishing a universal BCR HLA-DRB1 monoallelic APC platform To address shortcomings in the ability to interrogate HLA-DRB1 presentation of biotherapeutics and to better understand the specific allelic restriction from a broad range of alleles, we aimed to construct a monoallelic HLA-DRB1 APC platform capable of internalizing a wide range of biotherapeutic protein modalities (Fig