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Opioid analgesics are generally avoided in liver disease due to increased sensitivity, prolonged effects, and risk of encephalopathy in advanced liver disease, though they may occasionally be used under specialist supervision with careful dose adjustment

Also, co-infusion of a KATP channel blocker with GLP-1 into the arcuate nucleus inhibited the effect of GLP-1 on peripheral glucose metabolism [93]

Caruso G, Di Pietro L, Cardaci V, Maugeri S, Caraci F