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Endocr Rev 30(4):376408

doi: 10.3389/fendo.2025.1649270 Received 18 June 2025 Accepted 22 September 2025 Published 07 October 2025 Volume 16 - 2025 Edited by Lingling Wei, Capital Medical University, China Reviewed by Katy Sanchez-Pozos, Hospital Jurez de Mxico, Mexico Koyel Kar, BCDA College of Pharmacy and Technology, India brahim Sarbay, Gaziosmanpaa Training and Research Hospital, Trkiye Updates Copyright 2025 Gandecka-Pempera, Naskrt, Adamska and Zozuliska-Zikiewicz

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Additionally, research conducted in Spain indicated that the ApoE4 allele is more prevalent in familial PD but less common in sporadic PD compared to control groups, suggesting a potential risk association in individuals with specific genetic backgrounds (Blzquez et al., 2006)