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This alters EC properties through the production of a broad spectrum of proteases and coagulation factors, which disrupt NVU cells and contribute to BBB dysfunction, leading to prolonged inflammation [211, 213,214,215]

L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism

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In opioid-tolerant patients, the situation may be altered by the development of tolerance to opioid-related adverse reactions (see DOSAGE AND ADMINISTRATION)