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Bone mineral is more heterogeneously distributed in the femoral heads of osteoporotic and diabetic patients: a pilot study

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Specifically, phosphorylation of CARM1 at S217 by unknown kinase(s) blocks the binding of SAM to the catalytic site, whereas phosphorylation at S228, possibly by protein kinase C (PKC), disrupts CARM1's dimerization, ultimately restricting its methyltransferase activity during mitosis or dendritic maturation [91-93]

Autoimmune diseases and protein homeostasis Autoimmune diseases emerge from a catastrophic failure of immune tolerance, where the bodys defense system misidentifies its own cells as threats, leading to relentless inflammation and self-destruction

Different levels of ROS cause different effects