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182 Although colchicine was not originally intended to target NETs as a gout treatment, study had shown that colchicine impeded the production of NETs via reducing NOX2/ROS production and calcium influx

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The main mechanism of SGLT-2i is to act on the SGLT2 receptor of the proximal tubule, inhibit the reuptake of Na + and glucose, increase the excretion of glucose in urine to reduce blood glucose, and subsequently increase natriuria

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