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doi:10.1111/jdv.13690 97 Barroso, L

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It is a well-known component of many enzymatic proteins (selenoproteins), including glutathione peroxidase (GPx)

demonstrated that diacyl disulfides could produce H 2 S 2 in reaction with various nucleophiles including amines in both aqueous and organic environment [206]

Intuitively, generation of ROS in this process must be timely and spatially controlled to prevent excessive damage to the DNA: a recent report, in fact, describes a new role for the originally discovered superoxide dismutase, SOD1, that is recruited to the nucleus in response to specific stimuli 142