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Elevated plasma long-chain acylcarnitine primarily reflects systemic fatty acid oxidation damage, with strong and stable detection signals that effectively capture systemic metabolic dysregulation [124, 155, 156]

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A higher level of oxidative stress was detected in patients with NASH compared to NAFLD and a reduction in the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and GGT, as markers of oxidative stress, was highlighted in NASH patients treated with GSH, with a consequent reduction of alanine transaminase (ALT)

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The effects of 5-Amino-1MQ are linked to its ability to block Nicotinamide N-methyltransferase (NNMT) 1 , an enzyme involved in metabolism and aging